Gallery
Inflamed muscle
Extravasating neutrophils in the cremaster muscle captured by reflected light oblique transillumination microscopy
Migrating T Cells
Naïve CD8+ T cells (green) surveying a lymph node for antigen
DC scanning
Naïve CD4+ T cells (red) scanning the surface of dendritic cells expressing GFP-tagged MHC II molecules (green)
Antigen highways
Lymph-borne small (red) and large (green) antigens enter the lymph node and bind to antigen-specific B cells (blue)
Cytotoxic killing
Primed CTL (green) contact and lyse target B cells (purple) in a lymph node
Clean-up crew
Lymph node phagocytes accumulate B cell debris following the kill, while the sharks are still circling…
'Paralyzed' killers
Under the influence of Treg cells, CTL (green) fail to lyse their B cell targets
No touch paralysis
Treg cells (red) 'paralyze' CTL (green) without making direct contacts
Invasion
CTL (green) and Treg cells (red) infiltrate a solid tumor (blue nuclei)
Signal memory
NFAT (green) accumulates in the nucleus (red) in tumor-infiltrating CTL and transiently persists following each short-lived antigen encounter in a solid tumor
Containment
Upon laser injury (center of image) microglia (green) deploy their processes to insulate the damaged tissue
A healthy meal
Tumor-associated macrophages (green) accumulate vesicles and debris released from glioblastoma cells (red)
HIV makes sticky
Infected (green) but not uninfected (red) CD4+ T cells elongate due to HIV Env-mediated adhesion and syncytia formation.
Cancer motility
myf5+ cells zebrafish rhabdomyosarcoma cells (green) are sessile while myogenin+ cells (red) are highly migratory
Self-antigen love
CD4+ Treg (top) but not Tconv cells (bottom) recognize antigen in tumor tissue
Survival niches
CXCR6-expressing CTL (red) interact with IL-15-trans-presenting DC (yellow) in perivascular immune niches of the tumor stroma